Brett H Graham Selected Research

Succinate-CoA Ligases (Succinyl Coenzyme A Synthetases)

1/2016	Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant.
2/2014	Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion.

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Brett H Graham Research Topics

Disease

10	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 04/2002
2	Leigh Disease (Leigh's Disease) 10/2019 - 02/2009
2	Intellectual Disability (Idiocy) 01/2019 - 08/2012
2	VLCAD deficiency 02/2016 - 11/2015
2	Hypoglycemia (Reactive Hypoglycemia) 02/2016 - 08/2012
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 01/2015
2	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy) 01/2016 - 02/2014
2	Seizures (Absence Seizure) 11/2015 - 10/2014
2	Inborn Genetic Diseases (Disease, Hereditary) 09/2013 - 08/2013
1	Protein Deficiency 04/2022
1	Hypothyroidism 01/2021
1	Epilepsy (Aura) 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 10/2020
1	Inflammation (Inflammations) 01/2020
1	Chronic Disease (Chronic Diseases) 01/2020
1	Body Weight (Weight, Body) 01/2020
1	Hyperinsulinism (Hyperinsulinemia) 01/2020
1	Muscular Diseases (Myopathy) 10/2019
1	Maple Syrup Urine Disease 10/2019
1	Argininosuccinic Aciduria 10/2019
1	Multiple Carboxylase Deficiency (Deficiency, Multiple Carboxylase) 01/2019
1	Holocarboxylase Synthetase Deficiency 01/2019
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 12/2018
1	Congenital Heart Defects (Congenital Heart Defect) 10/2018
1	Neurodevelopmental Disorders 01/2018
1	Fibrosis (Cirrhosis) 11/2017
1	Kidney Diseases (Kidney Disease) 11/2017
1	Status Epilepticus (Complex Partial Status Epilepticus) 07/2017
1	Starvation 06/2017
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2017
1	Tuberous Sclerosis (Bourneville's Disease) 01/2017
1	Neoplasms (Cancer) 01/2017
1	Breast Neoplasms (Breast Cancer) 03/2016
1	Triple Negative Breast Neoplasms 03/2016
1	Neoplasm Metastasis (Metastasis) 03/2016
1	Friedreich Ataxia (Friedreich's Ataxia) 01/2016
1	Rare Diseases (Rare Disease) 01/2016
1	Mucopolysaccharidosis VII (Sly Syndrome) 01/2016
1	Methylmalonic acidemia 01/2016
1	Nervous System Diseases (Neurological Disorders) 11/2015
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 09/2015
1	Acidosis 09/2015
1	Glaucoma 07/2015
1	Retinal Degeneration 07/2015
1	Optic Atrophy 07/2015
1	Eye Diseases (Eye Disease) 07/2015
1	Myopathy with lactic acidosis and sideroblastic anemia 11/2014
1	Microcephaly 10/2014
1	Alacrima 10/2014
1	Lactic Acidosis 09/2013
1	Mitochondrial encephalopathy 09/2013
1	Schizencephaly 08/2012
1	Ketosis 08/2012
1	Autism Spectrum Disorder 08/2012
1	Failure to Thrive 08/2012
1	Down Syndrome (Down's Syndrome) 08/2012
1	VDAC Deficiency 06/2012
1	Ataxia (Dyssynergia) 01/2012

Drug/Important Bio-Agent (IBA)

9	Mitochondrial DNA (mtDNA)IBA 10/2020 - 02/2009
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2016
3	Fatty Acids (Saturated Fatty Acids)IBA 03/2016 - 11/2015
2	Long-Chain Acyl-CoA Dehydrogenase (Long-Chain-Acyl-Coenzyme A Dehydrogenase)IBA 02/2016 - 11/2015
2	Succinate-CoA Ligases (Succinyl Coenzyme A Synthetases)IBA 01/2016 - 02/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016 - 01/2015
2	EnzymesIBA 01/2016 - 08/2012
2	Ligases (Synthetase)IBA 01/2016 - 02/2014
2	Transaminases (Aminotransferases)IBA 11/2015 - 10/2014
1	Citric Acid (Citrate)FDA LinkGeneric 04/2022
1	Biological ProductsIBA 01/2020
1	C-PeptideIBA 01/2020
1	Insulin (Novolin)FDA Link 01/2020
1	Amino Acids FDA Link 10/2019
1	Argininosuccinic AcidIBA 10/2019
1	Isoleucine (L-Isoleucine)FDA Link 10/2019
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 10/2019
1	ChromatinIBA 01/2019
1	BiotinidaseIBA 01/2019
1	Histones (Histone)IBA 01/2019
1	fucokinaseIBA 12/2018
1	MyokinesIBA 11/2017
1	Poly (ADP-Ribose) Polymerase-1IBA 07/2017
1	SugarsIBA 06/2017
1	Glucose (Dextrose)FDA LinkGeneric 06/2017
1	trans-sodium crocetinate (crocetin)IBA 01/2017
1	Carnitine (L-Carnitine)FDA LinkGeneric 03/2016
1	Oncogene Proteins (Oncogene Protein)IBA 03/2016
1	Adenosine Triphosphate (ATP)IBA 03/2016
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 03/2016
1	acylcarnitineIBA 02/2016
1	GlucuronidaseIBA 01/2016
1	FrataxinIBA 01/2016
1	Transferrin (beta 2 Transferrin)IBA 11/2015
1	CalcineurinIBA 09/2015
1	Creatine Kinase (Creatine Phosphokinase)IBA 09/2015
1	Lactic Acid (Lactate)FDA LinkGeneric 09/2015
1	Rhodopsin (Visual Purple)IBA 07/2015
1	Indicators and Reagents (Reagents)IBA 01/2015
1	Methylmalonic AcidIBA 02/2014
1	A-Form DNA (A-DNA)IBA 08/2013
1	Protein Isoforms (Isoforms)IBA 06/2012